TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

LUBAC modulates signalling by various immune receptors. In TNF signalling, linear (also known as M1) ubiquitin enables full gene-activation and prevents cell death. However, the mechanisms underlying cell-death prevention remain ill-defined. We show that LUBAC activity enables TBK1 and IKKε recruitm...

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Publié dans:Nat Cell Biol
Auteurs principaux: Lafont, Elodie, Draber, Peter, Rieser, Eva, Reichert, Matthias, Kupka, Sebastian, de Miguel, Diego, Draberova, Helena, von Mässenhausen, Anne, Bhamra, Amandeep, Henderson, Stephen, Wojdyla, Katarzyna, Chalk, Avigayil, Surinova, Silvia, Linkermann, Andreas, Walczak, Henning
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6268100/
https://ncbi.nlm.nih.gov/pubmed/30420664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0229-6
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