LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

Ubiquitination and deubiquitination are crucial for assembly and disassembly of signaling complexes. LUBAC-generated linear (M1) ubiquitin is important for signaling via various immune receptors. We show here that the deubiquitinases CYLD and A20, but not OTULIN, are recruited to the TNFR1- and NOD2...

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Publicat a:Cell Rep
Autors principals: Draber, Peter, Kupka, Sebastian, Reichert, Matthias, Draberova, Helena, Lafont, Elodie, de Miguel, Diego, Spilgies, Lisanne, Surinova, Silvia, Taraborrelli, Lucia, Hartwig, Torsten, Rieser, Eva, Martino, Luigi, Rittinger, Katrin, Walczak, Henning
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688036/
https://ncbi.nlm.nih.gov/pubmed/26670046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.009
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