The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9

PCSK9 is a secreted protein that regulates plasma cholesterol levels and cardiovascular disease risk. Prior studies suggested the presence of an ER cargo receptor that recruits PCSK9 into the secretory pathway, but its identity has remained elusive. Here, we apply a novel approach that combines prox...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:eLife
Hauptverfasser: Emmer, Brian T, Hesketh, Geoffrey G, Kotnik, Emilee, Tang, Vi T, Lascuna, Paul J, Xiang, Jie, Gingras, Anne-Claude, Chen, Xiao-Wei, Ginsburg, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2018
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156083/
https://ncbi.nlm.nih.gov/pubmed/30251625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38839
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge