PCSK9 Modulates the Secretion But Not the Cellular Uptake of Lipoprotein(a) Ex Vivo: An Effect Blunted by Alirocumab

To elucidate how the proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor alirocumab modulates lipoprotein(a) [Lp(a)] plasma levels, the authors performed a series of Lp(a) uptake studies in primary human hepatocytes and dermal fibroblasts and measured Lp(a) secretion from human hepatocyt...

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Bibliografiska uppgifter
I publikationen:JACC Basic Transl Sci
Huvudupphovsmän: Villard, Elise F., Thedrez, Aurélie, Blankenstein, Jorg, Croyal, Mikaël, Tran, Thi-Thu-Trang, Poirier, Bruno, Le Bail, Jean-Christophe, Illiano, Stéphane, Nobécourt, Estelle, Krempf, Michel, Blom, Dirk J., Marais, A. David, Janiak, Philip, Muslin, Anthony J., Guillot, Etienne, Lambert, Gilles
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2016
Ämnen:
PRECLINICAL RESEARCH
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5753417/
https://ncbi.nlm.nih.gov/pubmed/29308438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2016.06.006
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