The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9

PCSK9 is a secreted protein that regulates plasma cholesterol levels and cardiovascular disease risk. Prior studies suggested the presence of an ER cargo receptor that recruits PCSK9 into the secretory pathway, but its identity has remained elusive. Here, we apply a novel approach that combines prox...

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Vydáno v:eLife
Hlavní autoři: Emmer, Brian T, Hesketh, Geoffrey G, Kotnik, Emilee, Tang, Vi T, Lascuna, Paul J, Xiang, Jie, Gingras, Anne-Claude, Chen, Xiao-Wei, Ginsburg, David
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2018
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156083/
https://ncbi.nlm.nih.gov/pubmed/30251625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38839
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