Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4

Plasma LDL is produced from catabolism of VLDL and cleared from circulation mainly via the hepatic LDL receptor (LDLR). Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes LDLR degradation, increasing plasma LDL-C levels. Circulating PCSK9 is mainly secreted by the liver, whereas VLDL is...

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Dades bibliogràfiques
Publicat a:J Lipid Res
Autors principals: Wang, Bingxiang, Shen, Yishi, Zhai, Lei, Xia, Xiaodan, Gu, Hong-mei, Wang, Maggie, Zhao, Yongfang, Chang, Xiaole, Alabi, Adekunle, Xing, Sijie, Deng, Shijun, Liu, Boyan, Wang, Guiqing, Qin, Shucun, Zhang, Da-wei
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8261665/
https://ncbi.nlm.nih.gov/pubmed/34118252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jlr.2021.100091
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