Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4

Plasma LDL is produced from catabolism of VLDL and cleared from circulation mainly via the hepatic LDL receptor (LDLR). Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes LDLR degradation, increasing plasma LDL-C levels. Circulating PCSK9 is mainly secreted by the liver, whereas VLDL is...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Wang, Bingxiang, Shen, Yishi, Zhai, Lei, Xia, Xiaodan, Gu, Hong-mei, Wang, Maggie, Zhao, Yongfang, Chang, Xiaole, Alabi, Adekunle, Xing, Sijie, Deng, Shijun, Liu, Boyan, Wang, Guiqing, Qin, Shucun, Zhang, Da-wei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8261665/
https://ncbi.nlm.nih.gov/pubmed/34118252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jlr.2021.100091
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