Role of Quinone Reductase 2 in the Antimalarial Properties of Indolone-Type Derivatives

Indolone-N-oxides have antiplasmodial properties against Plasmodium falciparum at the erythrocytic stage, with IC(50) values in the nanomolar range. The mechanism of action of indolone derivatives involves the production of free radicals, which follows their bioreduction by an unknown mechanism. In...

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Publicat a:Molecules
Autors principals: Cassagnes, Laure-Estelle, Rakotoarivelo, Nambinina, Sirigu, Serena, Pério, Pierre, Najahi, Ennaji, Chavas, Léonard M. G., Thompson, Andrew, Gayon, Régis, Ferry, Gilles, Boutin, Jean A., Valentin, Alexis, Reybier, Karine, Nepveu, Françoise
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155775/
https://ncbi.nlm.nih.gov/pubmed/28146103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22020210
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