Role of Quinone Reductase 2 in the Antimalarial Properties of Indolone-Type Derivatives

Indolone-N-oxides have antiplasmodial properties against Plasmodium falciparum at the erythrocytic stage, with IC(50) values in the nanomolar range. The mechanism of action of indolone derivatives involves the production of free radicals, which follows their bioreduction by an unknown mechanism. In...

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Publicado no:Molecules
Main Authors: Cassagnes, Laure-Estelle, Rakotoarivelo, Nambinina, Sirigu, Serena, Pério, Pierre, Najahi, Ennaji, Chavas, Léonard M. G., Thompson, Andrew, Gayon, Régis, Ferry, Gilles, Boutin, Jean A., Valentin, Alexis, Reybier, Karine, Nepveu, Françoise
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155775/
https://ncbi.nlm.nih.gov/pubmed/28146103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22020210
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