Association of NQO2 With UDP-Glucuronosyltransferases Reduces Menadione Toxicity in Neuroblastoma Cells

The balance between detoxification and toxicity is linked to enzymes of the drug metabolism Phase I (cytochrome P450 or oxidoreductases) and phase II conjugating enzymes (such as the UGTs). After the reduction of quinones, the product of the reaction, the quinols—if not conjugated—re-oxidizes sponta...

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Udgivet i:Front Pharmacol
Main Authors: Chhour, Monivan, Perio, Pierre, Gayon, Regis, Ternet-Fontebasso, Hélène, Ferry, Gilles, Nepveu, Françoise, Boutin, Jean A., Sudor, Jan, Reybier, Karine
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8142080/
https://ncbi.nlm.nih.gov/pubmed/34040527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.660641
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