Role of Quinone Reductase 2 in the Antimalarial Properties of Indolone-Type Derivatives

Indolone-N-oxides have antiplasmodial properties against Plasmodium falciparum at the erythrocytic stage, with IC(50) values in the nanomolar range. The mechanism of action of indolone derivatives involves the production of free radicals, which follows their bioreduction by an unknown mechanism. In...

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Bibliografiset tiedot
Julkaisussa:Molecules
Päätekijät: Cassagnes, Laure-Estelle, Rakotoarivelo, Nambinina, Sirigu, Serena, Pério, Pierre, Najahi, Ennaji, Chavas, Léonard M. G., Thompson, Andrew, Gayon, Régis, Ferry, Gilles, Boutin, Jean A., Valentin, Alexis, Reybier, Karine, Nepveu, Françoise
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155775/
https://ncbi.nlm.nih.gov/pubmed/28146103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22020210
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