AAV2-mediated GRP78 Transfer Alleviates Retinal Neuronal Injury by Downregulating ER Stress and Tau Oligomer Formation

PURPOSE: Retinal ganglion cell (RGC) death following axonal injury occurring in traumatic optic neuropathy (TON) causes irreversible vision loss. GRP78 is a molecular chaperone that enhances protein folding and controls activation of endoplasmic reticulum (ER) stress pathways. This study determined...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Ha, Yonju, Liu, Wei, Liu, Hua, Zhu, Shuang, Xia, Fan, Gerson, Julia E., Azhar, Nisha A., Tilton, Ronald G., Motamedi, Massoud, Kayed, Rakez, Zhang, Wenbo
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2018
Assuntos:
Retinal Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155472/
https://ncbi.nlm.nih.gov/pubmed/30267089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.18-24427
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