Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

BACKGROUND: We have evaluated the efficacy of targeting the toxic, oligomeric form of tau protein by passive immunotherapy in a mouse model of synucleinopathy. Parkinson’s disease and Lewy body dementia are two of the most common neurodegenerative disorders and are primarily characterized by the acc...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Neurodegener
Main Authors: Gerson, Julia E., Farmer, Kathleen M., Henson, Natalie, Castillo-Carranza, Diana L., Carretero Murillo, Mariana, Sengupta, Urmi, Barrett, Alan, Kayed, Rakez
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856311/
https://ncbi.nlm.nih.gov/pubmed/29544548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0245-9
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