Misfolded SOD1 pathology in sporadic Amyotrophic Lateral Sclerosis

Aggregation of mutant superoxide dismutase 1 (SOD1) is a pathological hallmark of a subset of familial ALS patients. However, the possible role of misfolded wild type SOD1 in human ALS is highly debated. To ascertain whether or not misfolded SOD1 is a common pathological feature in non-SOD1 ALS, we...

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Published in:Sci Rep
Main Authors: Paré, Bastien, Lehmann, Manuela, Beaudin, Marie, Nordström, Ulrika, Saikali, Stephan, Julien, Jean-Pierre, Gilthorpe, Jonathan D., Marklund, Stefan L., Cashman, Neil R., Andersen, Peter M., Forsberg, Karin, Dupré, Nicolas, Gould, Peter, Brännström, Thomas, Gros-Louis, François
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155098/
https://ncbi.nlm.nih.gov/pubmed/30242181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31773-z
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