Crystal structure of rhodopsin in complex with a mini-G(o) sheds light on the principles of G protein selectivity

Selective coupling of G protein (heterotrimeric guanine nucleotide–binding protein)–coupled receptors (GPCRs) to specific Gα-protein subtypes is critical to transform extracellular signals, carried by natural ligands and clinical drugs, into cellular responses. At the center of this transduction eve...

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Vydáno v:Sci Adv
Hlavní autoři: Tsai, Ching-Ju, Pamula, Filip, Nehmé, Rony, Mühle, Jonas, Weinert, Tobias, Flock, Tilman, Nogly, Przemyslaw, Edwards, Patricia C., Carpenter, Byron, Gruhl, Thomas, Ma, Pikyee, Deupi, Xavier, Standfuss, Jörg, Tate, Christopher G., Schertler, Gebhard F. X.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154990/
https://ncbi.nlm.nih.gov/pubmed/30255144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aat7052
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