Valproate augments Niraparib killing of tumor cells

PARP1 inhibitors are approved therapeutic agents in ovarian carcinomas, and have clinical activity in some breast cancers. As a single agent, niraparib killed ovarian and mammary tumor cells via an ATM-AMPK-ULK1 pathway which resulted in mTOR inactivation and the formation of autophagosomes, tempora...

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Bibliografiske detaljer
Udgivet i:Cancer Biol Ther
Main Authors: Booth, Laurence, Roberts, Jane L., Rais, Rumeesa, Poklepovic, Andrew, Dent, Paul
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154859/
https://ncbi.nlm.nih.gov/pubmed/29923797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2018.1472190
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