Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae

The monobactam scaffold is attractive for the development of new agents to treat infections caused by drug-resistant Gram-negative bacteria because it is stable to metallo-β-lactamases (MBLs). However, the clinically used monobactam aztreonam lacks stability to serine β-lactamases (SBLs) that are of...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Dean, Charles R., Barkan, David T., Bermingham, Alun, Blais, Johanne, Casey, Fergal, Casarez, Anthony, Colvin, Richard, Fuller, John, Jones, Adriana K., Li, Cindy, Lopez, Sara, Metzger, Louis E., Mostafavi, Mina, Prathapam, Ramadevi, Rasper, Dita, Reck, Folkert, Ruzin, Alexey, Shaul, Jacob, Shen, Xiaoyu, Simmons, Robert L., Skewes-Cox, Peter, Takeoka, Kenneth T., Tamrakar, Pramila, Uehara, Tsuyoshi, Wei, Jun-Rong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153799/
https://ncbi.nlm.nih.gov/pubmed/30061293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01200-18
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