Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae

The monobactam scaffold is attractive for the development of new agents to treat infections caused by drug-resistant Gram-negative bacteria because it is stable to metallo-β-lactamases (MBLs). However, the clinically used monobactam aztreonam lacks stability to serine β-lactamases (SBLs) that are of...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Dean, Charles R., Barkan, David T., Bermingham, Alun, Blais, Johanne, Casey, Fergal, Casarez, Anthony, Colvin, Richard, Fuller, John, Jones, Adriana K., Li, Cindy, Lopez, Sara, Metzger, Louis E., Mostafavi, Mina, Prathapam, Ramadevi, Rasper, Dita, Reck, Folkert, Ruzin, Alexey, Shaul, Jacob, Shen, Xiaoyu, Simmons, Robert L., Skewes-Cox, Peter, Takeoka, Kenneth T., Tamrakar, Pramila, Uehara, Tsuyoshi, Wei, Jun-Rong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153799/
https://ncbi.nlm.nih.gov/pubmed/30061293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01200-18
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