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Impact of Inducible bla(DHA-1) on Susceptibility of Klebsiella pneumoniae Clinical Isolates to LYS228 and Identification of Chromosomal mpl and ampD Mutations Mediating Upregulation of Plasmid-Borne bla(DHA-1) Expression
Twenty-three Klebsiella pneumoniae (bla(DHA-1)) clinical isolates exhibited a range of susceptibilities to LYS228, with MICs of ≥8 μg/ml for 9 of these. Mutants with decreased susceptibility to LYS228 and upregulated expression of bla(DHA-1) were selected from representative isolates. These had muta...
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| Publicado no: | Antimicrob Agents Chemother |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6153798/ https://ncbi.nlm.nih.gov/pubmed/30061296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01202-18 |
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