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Impact of Inducible bla(DHA-1) on Susceptibility of Klebsiella pneumoniae Clinical Isolates to LYS228 and Identification of Chromosomal mpl and ampD Mutations Mediating Upregulation of Plasmid-Borne bla(DHA-1) Expression

Twenty-three Klebsiella pneumoniae (bla(DHA-1)) clinical isolates exhibited a range of susceptibilities to LYS228, with MICs of ≥8 μg/ml for 9 of these. Mutants with decreased susceptibility to LYS228 and upregulated expression of bla(DHA-1) were selected from representative isolates. These had muta...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Antimicrob Agents Chemother
Κύριοι συγγραφείς: Jones, Adriana K., Ranjitkar, Srijan, Lopez, Sara, Li, Cindy, Blais, Johanne, Reck, Folkert, Dean, Charles R.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2018
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153798/
https://ncbi.nlm.nih.gov/pubmed/30061296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01202-18
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