Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae

The monobactam scaffold is attractive for the development of new agents to treat infections caused by drug-resistant Gram-negative bacteria because it is stable to metallo-β-lactamases (MBLs). However, the clinically used monobactam aztreonam lacks stability to serine β-lactamases (SBLs) that are of...

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Foilsithe in:Antimicrob Agents Chemother
Main Authors: Dean, Charles R., Barkan, David T., Bermingham, Alun, Blais, Johanne, Casey, Fergal, Casarez, Anthony, Colvin, Richard, Fuller, John, Jones, Adriana K., Li, Cindy, Lopez, Sara, Metzger, Louis E., Mostafavi, Mina, Prathapam, Ramadevi, Rasper, Dita, Reck, Folkert, Ruzin, Alexey, Shaul, Jacob, Shen, Xiaoyu, Simmons, Robert L., Skewes-Cox, Peter, Takeoka, Kenneth T., Tamrakar, Pramila, Uehara, Tsuyoshi, Wei, Jun-Rong
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2018
Ábhair:
Mechanisms of Resistance
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153799/
https://ncbi.nlm.nih.gov/pubmed/30061293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01200-18
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