Microdialysis Study of Aztreonam-Avibactam Distribution in Peritoneal Fluid and Muscle of Rats with or without Experimental Peritonitis

The purpose of this study was to investigate aztreonam (ATM) and avibactam (AVI) distribution in intraperitoneal fluid and muscle interstitial fluid by microdialysis in rats, with or without peritonitis, and to compare the unbound concentrations in tissue with the unbound concentrations in blood. Mi...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Chauzy, Alexia, Lamarche, Isabelle, Adier, Christophe, Couet, William, Marchand, Sandrine
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153784/
https://ncbi.nlm.nih.gov/pubmed/30012776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01228-18
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