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Microdialysis Study of Imipenem Distribution in the Peritoneal Fluid of Rats with Experimental Acute Pancreatitis

Imipenem distribution was characterized by microdialysis in the peritoneal fluid of rats with experimental pancreatitis. The ratios of peritoneal fluid to blood area under unbound concentration-versus-time curves were close to unity, suggesting that imipenem was not degraded in peritoneal fluid.

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Bibliographic Details
Main Authors: Lefeuvre, Sandrine, Marchand, Sandrine, Pariat, Claudine, Lamarche, Isabelle, Couet, William
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292542/
https://ncbi.nlm.nih.gov/pubmed/18195055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01474-07
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