Increased Doses Lead to Higher Drug Exposures of Levofloxacin for Treatment of Tuberculosis

Patients with multidrug-resistant tuberculosis in Peru and South Africa were randomized to a weight-banded nominal dose of 11, 14, 17, or 20 mg/kg/day levofloxacin (minimum, 750 mg) in combination with other second-line agents. A total of 101 patients were included in noncompartmental pharmacokineti...

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Wydane w:Antimicrob Agents Chemother
Główni autorzy: Peloquin, Charles A., Phillips, Patrick P. J., Mitnick, Carole D., Eisenach, Kathleen, Patientia, Ramonde F., Lecca, Leonid, Gotuzzo, Eduardo, Gandhi, Neel R., Butler, Donna, Diacon, Andreas H., Martel, Bruno, Santillan, Juan, Hunt, Kathleen Robergeau, Vargas, Dante, von Groote-Bidlingmaier, Florian, Seas, Carlos, Dianis, Nancy, Moreno-Martinez, Antonio, Kaur, Pawandeep, Horsburgh, C. Robert
Format: Artigo
Język:Inglês
Wydane: American Society for Microbiology 2018
Hasła przedmiotowe:
Pharmacology
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153781/
https://ncbi.nlm.nih.gov/pubmed/30012767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00770-18
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