Increased Doses Lead to Higher Drug Exposures of Levofloxacin for Treatment of Tuberculosis

Patients with multidrug-resistant tuberculosis in Peru and South Africa were randomized to a weight-banded nominal dose of 11, 14, 17, or 20 mg/kg/day levofloxacin (minimum, 750 mg) in combination with other second-line agents. A total of 101 patients were included in noncompartmental pharmacokineti...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Peloquin, Charles A., Phillips, Patrick P. J., Mitnick, Carole D., Eisenach, Kathleen, Patientia, Ramonde F., Lecca, Leonid, Gotuzzo, Eduardo, Gandhi, Neel R., Butler, Donna, Diacon, Andreas H., Martel, Bruno, Santillan, Juan, Hunt, Kathleen Robergeau, Vargas, Dante, von Groote-Bidlingmaier, Florian, Seas, Carlos, Dianis, Nancy, Moreno-Martinez, Antonio, Kaur, Pawandeep, Horsburgh, C. Robert
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153781/
https://ncbi.nlm.nih.gov/pubmed/30012767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00770-18
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