Increased Doses Lead to Higher Drug Exposures of Levofloxacin for Treatment of Tuberculosis

Patients with multidrug-resistant tuberculosis in Peru and South Africa were randomized to a weight-banded nominal dose of 11, 14, 17, or 20 mg/kg/day levofloxacin (minimum, 750 mg) in combination with other second-line agents. A total of 101 patients were included in noncompartmental pharmacokineti...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Peloquin, Charles A., Phillips, Patrick P. J., Mitnick, Carole D., Eisenach, Kathleen, Patientia, Ramonde F., Lecca, Leonid, Gotuzzo, Eduardo, Gandhi, Neel R., Butler, Donna, Diacon, Andreas H., Martel, Bruno, Santillan, Juan, Hunt, Kathleen Robergeau, Vargas, Dante, von Groote-Bidlingmaier, Florian, Seas, Carlos, Dianis, Nancy, Moreno-Martinez, Antonio, Kaur, Pawandeep, Horsburgh, C. Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153781/
https://ncbi.nlm.nih.gov/pubmed/30012767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00770-18
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