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Structural and immunological characterization of E. coli derived recombinant CRM(197) protein used as carrier in conjugate vaccines

It is established that the immunogenicity of polysaccharides is enhanced by coupling them to carrier proteins. Cross reacting material (CRM(197)), a nontoxic variant of diphtheria toxin (DT) is widely used carrier protein for polysaccharide conjugate vaccines. Conventionally, CRM(197) is isolated by...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Mishra, Ravi P.N., Yadav, Ravi S.P., Jones, Christopher, Nocadello, Salvatore, Minasov, George, Shuvalova, Ludmilla A., Anderson, Wayne F., Goel, Akshay
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153374/
https://ncbi.nlm.nih.gov/pubmed/29875175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20180238
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