Structural and immunological characterization of E. coli derived recombinant CRM(197) protein used as carrier in conjugate vaccines

It is established that the immunogenicity of polysaccharides is enhanced by coupling them to carrier proteins. Cross reacting material (CRM(197)), a nontoxic variant of diphtheria toxin (DT) is widely used carrier protein for polysaccharide conjugate vaccines. Conventionally, CRM(197) is isolated by...

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Библиографические подробности
Опубликовано в: :Biosci Rep
Главные авторы: Mishra, Ravi P.N., Yadav, Ravi S.P., Jones, Christopher, Nocadello, Salvatore, Minasov, George, Shuvalova, Ludmilla A., Anderson, Wayne F., Goel, Akshay
Формат: Artigo
Язык:Inglês
Опубликовано: Portland Press Ltd. 2018
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153374/
https://ncbi.nlm.nih.gov/pubmed/29875175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20180238
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