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Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation
Mutations in the KRAS proto-oncogene are present in 50% of all colorectal cancers and are increasingly associated with chemotherapeutic resistance to frontline biologic drugs. Accumulating evidence indicates key roles for overactive KRAS mutations in the metabolic reprogramming from oxidative phosph...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6153299/ https://ncbi.nlm.nih.gov/pubmed/30087121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001469 |
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