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Agonists of the γ-Aminobutyric Acid Type B (GABA(B)) Receptor Derived from β-Hydroxy and β-Amino Difluoromethyl Ketones

β-Hydroxy difluoromethyl ketones represent the newest class of agonists of the GABA(B) receptor, and they are structurally distinct from all other known agonists at this receptor because they do not display the carboxylic acid or amino group of γ-aminobutyric acid (GABA). In this report, the design,...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Sowaileh, Munia F., Salyer, Amy E., Roy, Kuldeep K., John, Jinu P., Woods, James R., Doerksen, Robert J., Hockerman, Gregory H., Colby, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152937/
https://ncbi.nlm.nih.gov/pubmed/29657102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.04.003
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