Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

Protein complexes are assemblies of subunits that have co-evolved to execute one or many coordinated functions in the cellular environment. Functional annotation of mammalian protein complexes is critical to understanding biological processes as well as disease mechanisms. Here, we used genetic co-e...

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Gepubliceerd in:Cell Syst
Hoofdauteurs: Pan, Joshua, Meyers, Robin M., Michel, Brittany C., Mashtalir, Nazar, Sizemore, Ann E., Wells, Jonathan N., Cassel, Seth H., Vazquez, Francisca, Weir, Barbara A., Hahn, William C., Marsh, Joseph A., Tsherniak, Aviad, Kadoch, Cigall
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152908/
https://ncbi.nlm.nih.gov/pubmed/29778836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2018.04.011
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