Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

Protein complexes are assemblies of subunits that have co-evolved to execute one or many coordinated functions in the cellular environment. Functional annotation of mammalian protein complexes is critical to understanding biological processes as well as disease mechanisms. Here, we used genetic co-e...

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發表在:Cell Syst
Main Authors: Pan, Joshua, Meyers, Robin M., Michel, Brittany C., Mashtalir, Nazar, Sizemore, Ann E., Wells, Jonathan N., Cassel, Seth H., Vazquez, Francisca, Weir, Barbara A., Hahn, William C., Marsh, Joseph A., Tsherniak, Aviad, Kadoch, Cigall
格式: Artigo
語言:Inglês
出版: 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152908/
https://ncbi.nlm.nih.gov/pubmed/29778836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2018.04.011
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