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Batch effects in single-cell RNA sequencing data are corrected by matching mutual nearest neighbours

Large-scale single-cell RNA sequencing (scRNA-seq) datasets that are produced in different laboratories and at different times contain batch effects that could compromise integration and interpretation of these data. Existing scRNA-seq analysis methods incorrectly assume that the composition of cell...

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Библиографические подробности
Опубликовано в: :Nat Biotechnol
Главные авторы: Haghverdi, Laleh, Lun, Aaron T. L., Morgan, Michael D., Marioni, John C.
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152897/
https://ncbi.nlm.nih.gov/pubmed/29608177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.4091
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