Repositioning FDA Drugs as Potential Cruzain Inhibitors from Trypanosoma cruzi: Virtual Screening, In Vitro and In Vivo Studies

Chagas disease (CD) is a neglected disease caused by the parasite Trypanosoma cruzi, which affects underdeveloped countries. The current drugs of choice are nifurtimox and benznidazole, but both have severe adverse effects and less effectivity in chronic infections; therefore, the need to discover n...

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Vydáno v:Molecules
Hlavní autoři: Palos, Isidro, Lara-Ramirez, Edgar E., Lopez-Cedillo, Julio Cesar, Garcia-Perez, Carlos, Kashif, Muhammad, Bocanegra-Garcia, Virgilio, Nogueda-Torres, Benjamin, Rivera, Gildardo
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152615/
https://ncbi.nlm.nih.gov/pubmed/28629155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22061015
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