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Repositioning FDA Drugs as Potential Cruzain Inhibitors from Trypanosoma cruzi: Virtual Screening, In Vitro and In Vivo Studies

Chagas disease (CD) is a neglected disease caused by the parasite Trypanosoma cruzi, which affects underdeveloped countries. The current drugs of choice are nifurtimox and benznidazole, but both have severe adverse effects and less effectivity in chronic infections; therefore, the need to discover n...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Molecules
Hauptverfasser: Palos, Isidro, Lara-Ramirez, Edgar E., Lopez-Cedillo, Julio Cesar, Garcia-Perez, Carlos, Kashif, Muhammad, Bocanegra-Garcia, Virgilio, Nogueda-Torres, Benjamin, Rivera, Gildardo
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152615/
https://ncbi.nlm.nih.gov/pubmed/28629155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22061015
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