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Solvent-Free Addition of Indole to Aldehydes: Unexpected Synthesis of Novel 1-[1-(1H-Indol-3-yl) Alkyl]-1H-Indoles and Preliminary Evaluation of Their Cytotoxicity in Hepatocarcinoma Cells

New 1-[1-(1H-indol-3-yl) alkyl]-1H-indoles, surprisingly, have been obtained from the addition of indole to a variety of aldehydes under neat conditions. CaO, present in excess, was fundamental for carrying out the reaction with paraformaldehyde. Under the same reaction conditions, aromatic and hete...

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Bibliografiske detaljer
Udgivet i:Molecules
Main Authors: Tocco, Graziella, Zedda, Gloria, Casu, Mariano, Simbula, Gabriella, Begala, Michela
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151463/
https://ncbi.nlm.nih.gov/pubmed/29039799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22101747
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