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Link between a high k(on) for drug binding and a fast clinical action: to be or not to be?
Review articles on binding kinetics essentially focus on drugs that dissociate slowly from their target since this is required for the successful treatment of many pathophysiological conditions. Recently, the therapeutic benefit of a high k(on) (i.e. the second order association rate constant) has a...
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| Publicado no: | Medchemcomm |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6151451/ https://ncbi.nlm.nih.gov/pubmed/30288218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00296g |
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