From receptor binding kinetics to signal transduction; a missing link in predicting in vivo drug-action

An important question in drug discovery is how to overcome the significant challenge of high drug attrition rates due to lack of efficacy and safety. A missing link in the understanding of determinants for drug efficacy is the relation between drug-target binding kinetics and signal transduction, pa...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nederpelt, Indira, Kuzikov, Maria, de Witte, Wilbert E. A., Schnider, Patrick, Tuijt, Bruno, Gul, Sheraz, IJzerman, Adriaan P., de Lange, Elizabeth C. M., Heitman, Laura H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658448/
https://ncbi.nlm.nih.gov/pubmed/29075004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14257-4
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