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From receptor binding kinetics to signal transduction; a missing link in predicting in vivo drug-action
An important question in drug discovery is how to overcome the significant challenge of high drug attrition rates due to lack of efficacy and safety. A missing link in the understanding of determinants for drug efficacy is the relation between drug-target binding kinetics and signal transduction, pa...
Uloženo v:
| Vydáno v: | Sci Rep |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5658448/ https://ncbi.nlm.nih.gov/pubmed/29075004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14257-4 |
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