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Effects of target binding kinetics on in vivo drug efficacy: k(off), k(on) and rebinding
BACKGROUND AND PURPOSE: Optimal drug therapy often requires continuing high levels of target occupancy. Besides the traditional pharmacokinetic contribution, target binding kinetics is increasingly considered to play an important role as well. While most attention has been focused on the dissociatio...
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| Publicado no: | Br J Pharmacol |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4945762/ https://ncbi.nlm.nih.gov/pubmed/27129075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13504 |
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