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Effects of target binding kinetics on in vivo drug efficacy: k(off), k(on) and rebinding
BACKGROUND AND PURPOSE: Optimal drug therapy often requires continuing high levels of target occupancy. Besides the traditional pharmacokinetic contribution, target binding kinetics is increasingly considered to play an important role as well. While most attention has been focused on the dissociatio...
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| 發表在: | Br J Pharmacol |
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| 主要作者: | |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
John Wiley and Sons Inc.
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4945762/ https://ncbi.nlm.nih.gov/pubmed/27129075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13504 |
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