Evidence for a Cyanine Link Between Propargylamine Drugs and Monoamine Oxidase Clarifies the Inactivation Mechanism

Successful propargylamine drugs such as deprenyl inactivate monoamine oxidase (MAO), a target in multi-faceted approaches to prevent neurodegeneration in the aging population, but the chemical structure and mechanism of the irreversible inhibition are still debated. We characterized the covalent cya...

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Bibliographic Details
Published in:Front Chem
Main Authors: Albreht, Alen, Vovk, Irena, Mavri, Janez, Marco-Contelles, Jose, Ramsay, Rona R.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985292/
https://ncbi.nlm.nih.gov/pubmed/29892597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2018.00169
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