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Quantitative Structure–Activity Relationship Modeling of Kinase Selectivity Profiles

The discovery of selective inhibitors of biological target proteins is the primary goal of many drug discovery campaigns. However, this goal has proven elusive, especially for inhibitors targeting the well-conserved orthosteric adenosine triphosphate (ATP) binding pocket of kinase enzymes. The human...

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Bibliografski detalji
Izdano u:Molecules
Glavni autori: Kothiwale, Sandeepkumar, Borza, Corina, Pozzi, Ambra, Meiler, Jens
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151389/
https://ncbi.nlm.nih.gov/pubmed/28925954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22091576
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