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Quantitative Structure–Activity Relationship Modeling of Kinase Selectivity Profiles

The discovery of selective inhibitors of biological target proteins is the primary goal of many drug discovery campaigns. However, this goal has proven elusive, especially for inhibitors targeting the well-conserved orthosteric adenosine triphosphate (ATP) binding pocket of kinase enzymes. The human...

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Pubblicato in:Molecules
Autori principali: Kothiwale, Sandeepkumar, Borza, Corina, Pozzi, Ambra, Meiler, Jens
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151389/
https://ncbi.nlm.nih.gov/pubmed/28925954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22091576
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