Environmental Enrichment and Social Isolation Mediate Neuroplasticity of Medium Spiny Neurons through the GSK3 Pathway

Resilience and vulnerability to neuropsychiatric disorders are linked to molecular changes underlying excitability that are still poorly understood. Here, we identify glycogen-synthase kinase 3β (GSK3β) and voltage-gated Na(+) channel Nav1.6 as regulators of neuroplasticity induced by environmentall...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Scala, Federico, Nenov, Miroslav N., Crofton, Elizabeth J., Singh, Aditya K., Folorunso, Oluwarotimi, Zhang, Yafang, Chesson, Brent C., Wildburger, Norelle C., James, Thomas F., Alshammari, Musaad A., Alshammari, Tahani K., Elfrink, Hannah, Grassi, Claudio, Kasper, James M., Smith, Ashley E., Hommel, Jonathan D., Lichti, Cheryl F., Rudra, Jai S., D’Ascenzo, Marcello, Green, Thomas A., Laezza, Fernanda
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150488/
https://ncbi.nlm.nih.gov/pubmed/29642012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.062
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