Environmental Enrichment and Social Isolation Mediate Neuroplasticity of Medium Spiny Neurons through the GSK3 Pathway

Resilience and vulnerability to neuropsychiatric disorders are linked to molecular changes underlying excitability that are still poorly understood. Here, we identify glycogen-synthase kinase 3β (GSK3β) and voltage-gated Na(+) channel Nav1.6 as regulators of neuroplasticity induced by environmentall...

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Publicat a:Cell Rep
Autors principals: Scala, Federico, Nenov, Miroslav N., Crofton, Elizabeth J., Singh, Aditya K., Folorunso, Oluwarotimi, Zhang, Yafang, Chesson, Brent C., Wildburger, Norelle C., James, Thomas F., Alshammari, Musaad A., Alshammari, Tahani K., Elfrink, Hannah, Grassi, Claudio, Kasper, James M., Smith, Ashley E., Hommel, Jonathan D., Lichti, Cheryl F., Rudra, Jai S., D’Ascenzo, Marcello, Green, Thomas A., Laezza, Fernanda
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150488/
https://ncbi.nlm.nih.gov/pubmed/29642012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.062
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