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Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells

Liver cancer is a progressive, irreversible and aggressive malignant disease, which has no effective chemotherapeutic drugs. RA-XII, a natural cyclopeptide isolated from the traditional Chinese medicine Rubia yunnanensis, exerts anti-cancer and anti-inflammatory activities. This work aimed to invest...

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Détails bibliographiques
Publié dans:Molecules
Auteurs principaux: Song, Lihua, Wang, Zhe, Wang, Yurong, Guo, Di, Yang, Jianhong, Chen, Lijuan, Tan, Ninghua
Format: Artigo
Langue:Inglês
Publié: MDPI 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150396/
https://ncbi.nlm.nih.gov/pubmed/29137114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22111934
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