Aggressive leukemia driven by MLL-AF9

We recently showed that cellular origin impacts the aggressiveness and the phenotype of acute myeloid leukemia (AML). Direct induction of the MLL-AF9 fusion in various hematopoietic compartments in vivo using a doxycycline (DOX) regulated mouse model (iMLL-AF9) led to an invasive chemoresistant AML...

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Bibliographic Details
Published in:Mol Cell Oncol
Main Authors: Stavropoulou, Vaia, Peters, Antoine H. F. M., Schwaller, Juerg
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149880/
https://ncbi.nlm.nih.gov/pubmed/30250880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2016.1241854
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