Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model

Acute myeloid leukemia (AML) is a hierarchical hematopoietic malignancy originating from leukemic stem cells (LSCs). Autophagy is a lysosomal degradation pathway that is hypothesized to be important for the maintenance of AML as well as contribute to chemotherapy response. Here we employ a mouse mod...

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Foilsithe in:Cell Death Dis
Main Authors: Liu, Qiang, Chen, Longgui, Atkinson, Jennifer M, Claxton, David F, Wang, Hong-Gang
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2016
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Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059867/
https://ncbi.nlm.nih.gov/pubmed/27607576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.264
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