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Targeting kinases with precision

Cancer genomics and mechanistic studies have revealed that heterogeneous mutations within a single kinase can result in a variety of activation mechanisms. The challenge has been to match these insights with tailored drug discovery strategies to yield potent, highly selective drugs. With optimized d...

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Detalhes bibliográficos
Publicado no:Mol Cell Oncol
Main Authors: Gardino, Alexandra K., Evans, Erica K., Kim, Joseph L., Brooijmans, Natasja, Hodous, Brian L., Wolf, Beni, Lengauer, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149809/
https://ncbi.nlm.nih.gov/pubmed/30250891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2018.1435183
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