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Targeting kinases with precision

Cancer genomics and mechanistic studies have revealed that heterogeneous mutations within a single kinase can result in a variety of activation mechanisms. The challenge has been to match these insights with tailored drug discovery strategies to yield potent, highly selective drugs. With optimized d...

詳細記述

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書誌詳細
出版年:Mol Cell Oncol
主要な著者: Gardino, Alexandra K., Evans, Erica K., Kim, Joseph L., Brooijmans, Natasja, Hodous, Brian L., Wolf, Beni, Lengauer, Christoph
フォーマット: Artigo
言語:Inglês
出版事項: Taylor & Francis 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149809/
https://ncbi.nlm.nih.gov/pubmed/30250891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2018.1435183
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