Custom made inclusion bodies: impact of classical process parameters and physiological parameters on inclusion body quality attributes

BACKGROUND: The bacterium E. coli is a major host for recombinant protein production of non-glycosylated products. Depending on the expression strategy, the recombinant protein can be located intracellularly. In many cases the formation of inclusion bodies (IBs), protein aggregates inside of the cyt...

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Detalles Bibliográficos
Publicado en:Microb Cell Fact
Main Authors: Slouka, Christoph, Kopp, Julian, Hutwimmer, Stefan, Strahammer, Michael, Strohmer, Daniel, Eitenberger, Elisabeth, Schwaighofer, Andreas, Herwig, Christoph
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2018
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148765/
https://ncbi.nlm.nih.gov/pubmed/30236107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-018-0997-5
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