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Synthesis and biological evaluation of novel 5-chloro-N-(4-sulfamoylbenzyl) salicylamide derivatives as tubulin polymerization inhibitors

A novel series of sulfonamide derivatives, coupled with a salicylamide scaffold, was designed and synthesized. The structures of the synthesized compounds were established using (1)H NMR, (13)C NMR and high-resolution mass spectroscopy. The synthesized compounds were tested in vitro against five typ...

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Wydane w:Medchemcomm
Główni autorzy: Galal, Alaaeldin M. F., Soltan, Maha M., Ahmed, Esam R., Hanna, Atef G.
Format: Artigo
Język:Inglês
Wydane: Royal Society of Chemistry 2018
Hasła przedmiotowe:
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148682/
https://ncbi.nlm.nih.gov/pubmed/30288225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00214b
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