Phenothiazine antioxidants increase mitochondrial biogenesis and frataxin levels in Friedreich's ataxia cells

Friedreich's ataxia (FRDA) is a progressive neurodegenerative disease that is linked to transcriptional repression of the nuclear FXN gene encoding the essential mitochondrial protein frataxin (FXN). Compounds that increase frataxin levels may enable effective therapeutic intervention for blunt...

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Xehetasun bibliografikoak
Argitaratua izan da:Medchemcomm
Egile Nagusiak: Khdour, Omar M., Bandyopadhyay, Indrajit, Visavadiya, Nishant P., Roy Chowdhury, Sandipan, Hecht, Sidney M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Royal Society of Chemistry 2018
Gaiak:
Chemistry
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148561/
https://ncbi.nlm.nih.gov/pubmed/30288223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00274f
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